United States securities and exchange commission logo





                               October 28, 2021

       Danny Yeung
       Director
       Prenetics Global Limited
       Unit 701-706, K11 Atelier King   s Road
       728 King   s Road, Quarry Bay
       Hong Kong

                                                        Re: Prenetics Global
Limited
                                                            Draft Registration
Statement on Form F-4
                                                            Submitted September
30, 2021
                                                            CIK 0001876431

       Dear Mr. Yeung:

              We have reviewed your draft registration statement and have the
following comments. In
       some of our comments, we may ask you to provide us with information so
we may better
       understand your disclosure.

              Please respond to this letter by providing the requested
information and either submitting
       an amended draft registration statement or publicly filing your
registration statement on
       EDGAR. If you do not believe our comments apply to your facts and
circumstances or do not
       believe an amendment is appropriate, please tell us why in your
response.

             After reviewing the information you provide in response to these
comments and your
       amended draft registration statement or filed registration statement, we
may have additional
       comments.

       Draft Registration Statement on Form F-4

       Cover Page

   1.                                                   Please disclose
prominently on the cover page that you are not a Hong Kong operating
                                                        company but a Cayman
Islands holding company. Clarify whether your operations are
                                                        conducted by
subsidiaries and/or through contractual arrangements with variable interest
                                                        entities (VIEs) based
in China, and that this structure involves unique risks to investors. If
                                                        applicable, explain
whether the VIE structure is used to replicate foreign investment in
                                                        Chinese-based companies
where Chinese law prohibits direct foreign investment in the
                                                        operating companies,
and disclose that investors may never directly hold equity interests
                                                        in the Chinese
operating company. Your disclosure should acknowledge that Chinese
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FirstName  LastNameDanny
Prenetics Global Limited Yeung
Comapany
October 28,NamePrenetics
            2021         Global Limited
October
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         regulatory authorities could disallow this structure, which would
likely result in a material
         change in your operations and/or value of your ordinary shares,
including that it could
         cause the value of such securities to significantly decline or become
worthless. Provide a
         cross-reference to your detailed discussion of risks facing the
company and the offering as
         a result of this structure.
2.       Please revise the cover page to:
             disclose the expected ownership percentages in the combined
company of Artisan's
             public shareholders, the Sponsor, the Forward Purchase Investors,
the PIPE Investors,
             Prenetics existing shareholders other than Danny Yeung and Danny
Yeung if the
             business combination is approved and consummated; and
             quantify the business combination consideration.
3.       We note your disclosure indicating that Danny Yeung will beneficially
own
         approximately 60.7% of the total voting power of all issued and
outstanding PubCo
         Ordinary Shares following the consummation of the Business Combination
(subject to
         various assumptions). Please advise whether you will be a controlled
company under
         Nasdaq rules. If so, please (i) include appropriate disclosure on the
prospectus cover page,
         in the Prospectus Summary and Management of PubCo sections and provide
risk factor
         disclosure of this status and (ii) disclose the corporate governance
exemptions available to
         a controlled company and whether you intend to rely on these
exemptions.
4.       Provide prominent disclosure about the legal and operational risks
associated with being
         based in or having the majority of the company   s operations in Hong
Kong and China.
         Your disclosure should make clear whether these risks could result in
a material change in
         your operations and/or the value of your ordinary shares or could
significantly limit or
         completely hinder your ability to offer or continue to offer
securities to investors and
         cause the value of such securities to significantly decline or be
worthless. Your disclosure
         should address how recent statements and regulatory actions by China
s government, such
         as those related to the use of variable interest entities and data
security or anti-monopoly
         concerns, has or may impact the company   s ability to conduct its
business, accept foreign
         investments, or list on an U.S. or other foreign exchange. Your
prospectus summary
         should address, but not necessarily be limited to, the risks
highlighted on the prospectus
         cover page.
5.       Clearly disclose how you will refer to the holding company,
subsidiaries, and VIEs, if
         applicable, when providing the disclosure throughout the document so
that it is clear to
         investors which entity the disclosure is referencing and which
subsidiaries or entities are
         conducting the business operations. Refrain from using terms such as
 we    or    our    when
         describing activities or functions of a VIE, if applicable. Disclose
clearly the entity
         (including the domicile) in which investors are purchasing their
interest.
Industry and Market Data, page 3

6.       We note your statements that (i) the accuracy and completeness of
information used in
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Prenetics Global Limited Yeung
Comapany
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            2021         Global Limited
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         industry reports, publications, research, studies and forecasts is not
guaranteed and (ii) you
         have not independently verified data from industry sources. We further
note your
         statement on page 175 that neither you nor any other party has
independently verified the
         information presented in this section and that neither you nor any
other party makes any
         representation as to the accuracy or completeness of such information.
These statements
         may imply an inappropriate disclaimer of responsibility with respect
to such information
         that appears in the proxy statement/prospectus. Please either delete
these statements or
         specifically state that you or a named expert, as applicable, are
liable for such information.
Questions and Answers About the Proposals
What shall be the relative equity stakes of Artisan shareholders, Prenetics
shareholders and the
PIPE Investors..., page 8

7.       Please revise the response to this question to also include the voting
power of the parties
         that appear in the share ownership table.
8.       Please revise the response to this question to disclose all possible
sources and extent of
         dilution that shareholders who elect not to redeem their shares may
experience in
         connection with the business combination. Provide disclosure of the
impact of each
         significant source of dilution, including the amount of equity held by
founders,
         convertible securities, including warrants retained by redeeming
shareholders, at each of
         the redemption levels detailed in your sensitivity analysis, including
any needed
         assumptions.
What interests do Artisan's Directors and Officer have in the Business
Combination?, page 13

9.       Please revise the response to this question and elsewhere in the
prospectus, as appropriate,
         to clarify if the Sponsor and its affiliates can earn a positive rate
of return on their
         investment, even if other Artisan shareholders experience a negative
rate of return in the
         post-business combination company.
10.      Please revise the response to this question and elsewhere in the
prospectus, as
         appropriate, to disclose the sponsor and its affiliates    total
potential ownership interest in
         the combined company, assuming exercise and conversion of all
securities.
Summary of the Proxy Statement/Prospectus, page 23

11.      Clearly describe the corporate structure and whether it includes VIEs
based in China and
         what that entails. Prominently disclose a diagram of the corporate
structure in the
         summary, including what the equity ownership interests are of each
entity. To the extent
         you do use VIEs, describe all contracts and arrangements through which
you purport to
         obtain economic rights and exercise control that results in
consolidation of the VIE   s
         operations and financial results into your financial statements.
Identify clearly the entity in
         which investors are purchasing their interest and the entity(ies) in
which the company   s
         operations are conducted. Describe the relevant contractual agreements
between the
         entities and how this type of corporate structure may affect investors
and the value of their
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FirstName  LastNameDanny
Prenetics Global Limited Yeung
Comapany
October 28,NamePrenetics
            2021         Global Limited
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         investment, including how and why the contractual arrangements may be
less effective
         than direct ownership and that the company may incur substantial costs
to enforce the
         terms of the arrangements. Disclose the uncertainties regarding the
status of the rights of
         the Cayman Islands holding company with respect to any applicable
contractual
         arrangements with the VIE, its founders and owners, and the challenges
the company may
         face enforcing these contractual agreements due to uncertainties under
Chinese law and
         jurisdictional limits.
12.      Prominently disclose each permission that you, your subsidiaries or
your VIEs, if
         applicable, are required to obtain from Chinese authorities to operate
and issue these
         securities to foreign investors. State whether you, your subsidiaries,
or VIEs, if
         applicable, are covered by permissions requirements from the CSRC, CAC
or any other
         entity that is required to approve of the VIE   s or the subsidiary
s operations, and state
         affirmatively whether you have received all requisite permissions and
whether any
         permissions have been denied.
13.      Please disclose the composition of the board of directors of PubCo
after consummation of
         the Business Combination in relation to members associated with each
of the pre-
         acquisition entities.
14.      In your summary of risk factors, disclose the risks that your
corporate structure and being
         based in or having the majority of the company   s operations in Hong
Kong poses to
         investors. In particular, describe the significant regulatory,
liquidity, and enforcement
         risks with cross-references to the more detailed discussion of these
risks in the
         prospectus. For example, specifically discuss risks arising from the
legal system in China
         and Hong Kong, including risks and uncertainties regarding the
enforcement of laws and
         that rules and regulations in China and Hong Kong can change quickly
with little advance
         notice; and the risk that the Chinese government may intervene or
influence your
         operations at any time, or may exert more control over offerings
conducted overseas
         and/or foreign investment in China-based or Hong Kong-based issuers,
which could result
         in a material change in your operations and/or the value of your
ordinary
         shares. Acknowledge any risks that any actions by the Chinese
government to exert more
         oversight and control over offerings that are conducted overseas
and/or foreign investment
         in China-based or Hong Kong-based issuers could significantly limit or
completely hinder
         your ability to offer or continue to offer securities to investors and
cause the value of such
         securities to significantly decline or be worthless.
15.      Prominently disclose that trading in your securities may be prohibited
under the Holding
         Foreign Companies Accountable Act and your shares could be prohibited
from trading if
         the PCAOB determines that it cannot inspect or fully investigate your
auditor, and that as
         a result an exchange may determine to delist your securities. If the
PCAOB has been or is
         currently unable to inspect your auditor, revise your disclosure to so
state. Please ensure
         that your disclosure indicates that the U.S. Senate passed the
Accelerating Holding
         Foreign Companies Accountable Act which, if enacted, would require
foreign companies
         to comply with PCAOB audits within two consecutive years instead of
three, thus
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Prenetics Global Limited Yeung
Comapany
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         reducing the time period for triggering the prohibition on trading.
The Artisan Board's Reasons for the Approval of the Business Combination, page
27

16.      Please revise your disclosure here and on page 143 to disclose whether
Artisan's Board
         considered any risks related to Prenetics's business in evaluating
whether to approve the
         Business Combination. To the extent Artisan's Board considered any
such risks, please
         describe them. If Artisan's Board did not consider any such risks,
please so state and
         disclose why the Artisan Board did not consider risks related to
Prenetics's business in its
         decision to approve the Business Combination.
17.      Please revise the Financial Performance bullet here and on page 142 to
reflect your
         disclosure elsewhere in the prospectus that a significant majority of
the Prenetics's
         revenue growth in 2020 and in 2021 to date was driven by COVID-19
diagnostic testing.
         Please also revise this bullet to reflect your disclosure on page 146
indicating that
         Prenetics's management projected net losses in each of Prenetics's
next five fiscal years.
18.      Please revise the Continued Support by Existing Shareholders bullet to
briefly disclose
         how long the post-closing lock-up arrangements for major shareholders
of Prenetics will
         last.
19.      Please revise this section to disclose the material risks to
unaffiliated investors presented
         by taking the company public through a merger rather than an
underwritten offering.
         These risks could include the absence of due diligence conducted by an
underwriter that
         would be subject to liability for any material misstatements or
omissions in a registration
         statement.
Risk Factors, page 48

20.      Please revise both the Risk Factor Summary and the Risk Factors
section to prominently
         display and discuss the risks of doing business in Hong Kong.
21.      Given the Chinese government   s significant oversight and discretion
over the conduct of
         your business, please revise to separately highlight the risk that the
Chinese government
         may intervene or influence your operations at any time, which could
result in a material
         change in your operations and/or the value of your ordinary shares.
Also, given recent
         statements by the Chinese government indicating an intent to exert
more oversight and
         control over offerings that are conducted overseas and/or foreign
investment in China-
         based issuers, acknowledge the risk that any such action could
significantly limit or
         completely hinder your ability to offer or continue to offer
securities to investors and
         cause the value of such securities to significantly decline or be
worthless.
22.      In light of recent events indicating greater oversight by the
Cyberspace Administration of
         China over data security, particularly for companies seeking to list
on a foreign exchange,
         please revise your disclosure to explain how this oversight impacts
your business and your
         offering and to what extent you believe that you are compliant with
the regulations or
         policies that have been issued by the CAC to date.
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FirstName  LastNameDanny
Prenetics Global Limited Yeung
Comapany
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            2021         Global Limited
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Prenetics's business, financial condition and results of operations and/or the
value of PubCo's
shares..., page 74

23.      We note your statement on page 74 that Prenetics "does not have
business operations and
         does not offer its services and products in Mainland China." However,
we also note the
         list of subsidiaries on page F-31 that you state "principally affected
the results, assets or
         liabilities of the Group", four of which are incorporated in the PRC,
and the joint venture
         with Berry Genomics operating as a genetic testing company in mainland
China of which
         Prenetics owns 45%. Please revise your disclosure throughout the
document to clearly
         describe all operations, whether direct or indirect, that Prenetics
conducts in Mainland
         China.
Organizational Structure, page 129

24.      We note that "indirect subsidiaries" of Prenetics are shown in the
post-Business
         Combination org chart on page 131. Please clarify the nature and
extent of Prenetic's
         ownership of these entities on a post-combination basis.
Background of the Business Combination, page 131

25.      We note your statement that the disclosure in this section is not, and
does purport to be, a
         complete catalogue of every interaction between the applicable
parties. Please revise your
         disclosure to clarify that you are required to present all material
information regarding the
         negotiation of the Business Combination to investors. Please also
ensure that this section
         contains all such information.
26.      Your disclosure on page 133 indicates that Artisan and Prenetics held
a due diligence call
         on June 2, 2021 regarding Prenetics's historical financials and
management projections for
         its respective business segments. Please tell us if this information
was presented to
         Artisan's Board. To the extent that this information was presented to
Artisan's Board and
         that Artisan's Board considered it in its decision to approve the
Business Combination,
         please include it in the prospectus.
27.      Please revise your disclosure in this section to disclose how
Artisan's management and the
         Artisan Board determined a pre-money equity valuation of $1.15 billion
for Prenetics. To
         the extent that this valuation changed between the signing of the LOI
on June 21, 2021
         and the execution of the definitive agreement, please describe any
such changes. In that
         regard, we note that the press releases announcing the transaction
refer to an enterprise
         value of $1.25 billion for Prenetics.

         Please also revise to present the "analysis of Prenetics's valuation
in a potential business
         combination with Artisan" described on page 134 as being reviewed by
Artisan's board on
         June 17, 2021 and ensure that all material information from the
presentation to PIPE
         investors referenced throughout this section is included in the proxy
statement/prospectus.
28.      Please revise the disclosure concerning the Artisan Board's reasons
for approval of the
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         Business Combination in the subsections beginning on page 27 and page
140 to discuss
         whether the Artisan Board considered forming an independent committee
to evaluate the
         Business Combination given your disclosure that an affiliate of the
Sponsor 1) entered
         into a collaboration agreement with Prenetics while transaction
negotiations between
         Prenetics and Artisan were ongoing, and 2) entered into a convertible
note subscription
         agreement with Prenetics Limited in February 2021, the same month that
Artisan was
         incorporated.
Certain Prospective Operational and Financial Information, page 145

29.      In regards to the Prenetics Management Projections, please expand your
disclosures to
         address the following:
             Further explain the nature of the material assumptions underlying
the line items
              presented. Please ensure the level of detail provided is
sufficient enough for an
              investor to understand the reasonableness of the assumptions
underlying
              the projections as well as the inherent limitations on the
reliability of projections in
              order to make informed investment decisions. In regards to the
revenue and gross
              margin projected amounts, please specifically address the
significant revenue and
              gross margin growth rates as well as identify the material
product revenues streams
              underlying these projections;
             In regards to the length of the projections, please disclose the
basis for projections
              beyond year three including if the forecasts reflect more than
simple assumptions
              about growth rates;
             Explain how management and the Board considered and relied upon
these
              projections; and
             In the reconciliation from Adjusted EBITDA to Net Profit, please
further clarify the
              other non-operating expenses being excluded from the
determination of Adjusted
              EBITDA.
Certain Engagements in connection with the Business Combination and Related
Transactions,
page 149

30.      We note that UBS and Credit Suisse performed additional services after
the IPO and part
         of the IPO underwriting fee was deferred and conditioned on completion
of a business
         combination. Please quantify the aggregate fees payable to UBS and
Credit Suisse that are
         contingent on completion of the business combination.
Prenetics's Business
Overview, page 185

31.      We note your statement on pages 185-86 that the nucleic acid
amplification test achieved
         95.6% sensitivity and 100% specificity. Please revise your disclosure
to clarify whether
         this study was evaluating the Circle HealthPod. Please also revise
your disclosure in this
         section, where appropriate, to describe the study's material
parameters including the
         number of participants enrolled, primary endpoints and duration.
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32.      Please revise this section, where appropriate, to describe the
material terms of Prenetics's
         acquisition of Oxsed, including any earnouts.
Our History, page 187

33.      We note that you identify certain entities as investors in Prenetics.
However, certain of
         these entities do not appear to be among PubCo's principal
stockholders as disclosed on
         page 283. If material, please expand your disclosure to describe the
nature of each such
         entity's investment in Prenetics and explain to us why including this
information is
         appropriate. Please also explain in the response your plans to update
investors about any
         changes these entities make with respect to their investments in your
company.
         Alternatively, please remove these entities from your disclosure.
Circle HealthPod, page 194

34.      We note your statements on page 196 indicating that New World
Development has
         purchased Circle HealthPod devices and capsules and on page 203 that
Prenetics's
         collaboration with New World Development provides a strong testament
of its
         commercial strategy. Please revise each of these statements to reflect
your disclosure
         elsewhere in the prospectus that Adrian Cheng, the founder of Artisan
and the Sponsor, is
         also the CEO and executive vice chairman of New World Development and
that
         the collaboration was entered into while Artisan and Prenetics were
negotiating the terms
         of the Business Combination.
Our Pipeline Products and Services, page 196

35.      We note your statement on page 196 indicating that ColoClear has an
estimated 95.5%
         sensitivity. Please revise your disclosure in the Prenetics's Business
section, where
         appropriate, to describe the material protocols of the study(ies)
where ColoClear was
         evaluated (including number of patients treated and primary endpoints)
and how it was
         determined that ColoClear has estimated 95.5% sensitivity. Please also
revise to disclose
         whether Prenetics will need to obtain regulatory approvals before it
can commercialize
         ColoClear.
Intellectual Property, page 207

36.      Please disclose the jurisdictions of Prenetics's pending patent
applications and the
         expiration dates, if the patents are issued.
37.      Please revise the description of each of the license agreements in
this section to disclose:
             each parties' rights and obligations under the agreement;
             quantify all payment made to date;
             disclose separately the aggregate amount of all potential
development, regulatory and
             commercial milestone payments;
             quantify the royalty rate, or a range no greater than 10
percentage points per tier;
             disclose when royalty provisions expire, if the expiration is
based on a number of
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              years following commercialization, disclose the number of years;
                disclose the expiration date; and
                describe any termination provisions.
Description of the Business Combination, page 237

38.      Please also disclose the terms of the conversion of Artisan Class A
and Artisan Class B
         shares into Class A and Class B of PubCo shares. It appears that
holders of Artisan Class
         B shares are receiving Class A shares of PubCo.
Note 3. Prenetics Corporate Restructuring, page 248

39.      As part of the restructuring in June 2021, the convertible securities
of Prenetics Limited
         were converted into Series D Preferred Shares of Prenetics Group
Limited. Please
         disclose the key terms of these preferred shares and correspondingly
how you determined
         equity classification was appropriate under IAS 32.
40.      Please also disclose the material terms of the Series E Funding,
including the key terms of
         these Series E preferred shares and correspondingly how you determined
equity
         classification was appropriate under IAS 32.
Unaudited Pro Forma Condensed Combined Financial Information
Note 4. Adjustments to Unaudited Pro Forma Condensed Combined Financial
Information, page
248

41.      As part of the business combination transaction, restricted share
units previously held will
         be converted into PubCo restricted share units. Please disclose how
you will be
         accounting for this exchange under IFRS 2 and correspondingly how you
determined that
         the conversion would lead to the elimination of share-based
compensation expense as
         addressed in Adjustment DD.
42.      In regards to Adjustment O and EE, please expand your disclosures to
further address how
         this amount was determined, including the significant estimates and
assumptions used to
         arrive at this pro forma expense amount as well as the calculation
used.
Description of PubCo Securities
Ordinary Shares, page 270

43.      Please revise your disclosure to provide the definition of a
"Permitted Transferee" of a
         holder of Class B Ordinary Shares.
Report of Independent Registered Public Accounting Firm, page F-2

44.      We note that the Independent Auditor   s Report does not include an
opinion on the
         consolidated statements of financial position of Prenetics Limited and
subsidiaries as of
         January 1, 2019. Please provide a revised report or advise.
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(a) Statement of Compliance, page F-7

45.      You state that although IFRSs have been fully converged with IFRSs in
all material
         respects since January 1, 2005, these financial statements are the
first issued financial
         statements in which the Group makes an explicit and unreserved
statement of compliance
         with IFRSs. It is not clear if there is a typographical error when
stating that "although
         IFRSs have been fully converged with IFRSs." Please revise as
necessary.
Notes to the Consolidated Financial Statements, page F-6

46.      We note the various patent license as well as collaboration agreements
disclosed
         beginning on page 207. Please disclose the aggregate payments made
under these
         agreements as well as the material terms of these agreements,
including the following:
             each parties    rights and obligations;
             financial terms, including potential milestone payments and
royalty payments;
             duration of the agreement; and
             termination provisions.
(d) Subsidiaries and Non-controlling Interests, page F-8

47.      We note that the Group controls an entity when it is exposed, or has
rights, to variable
         returns from its involvement with the entity and has the ability to
affect those returns
         through its power over the entity. When assessing whether the Group
has power, only
         substantive rights (held by the Group and other parties) are
considered. Please tell us
         whether you have consolidated any entities for which you have
determined that you have
         power over the entities though do not have the majority of the voting
rights pursuant to
         IFRS 10.
Note 2. Significant Accounting Policies
(q) Revenue and Other Income, page F-14

48.      Pursuant to IFRS 15.119(b), please clarify in your disclosures whether
any of
         your consideration amounts are variable and whether the estimate of
variable
         consideration is typically constrained.
Note 3. Segment Information, page F-21

49.      Please tell us what consideration you gave to providing the product
and services
         disclosures under IFRS 8.32. Specifically we note the different
products and services
         disclosed including on page F-7 and we also note the update services
discussed on page
         F-15.
Note 5. Other Income and Other Net Losses, page F-23

50.      We note you include other income and other net losses and share of
loss of a joint venture
         in your determination of loss from operations. Please help us better
understand how you
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         determined it was appropriate to include net exchange losses,
impairment loss on interest
         in joint venture, sundry income, bank interest income, and share of
loss of a joint venture
         in your determination of loss from operations. Please refer to IAS
1.BC56 and Rule 5-
         03(b) of Regulation S-X.
Note 13. Interest in Joint Venture, page F-31

51.      In regards to your joint venture, please address the following:
             Pursuant to IFRS 12.22, please disclose the nature and extent of
any significant
              restrictions on the ability of the joint venture to transfer
funds to you as well as the
              unrecognised share of losses both for the reporting period and
cumulatively as you
              have stopped recognising your share of losses of the joint
venture;
             We note that there are amounts due from the joint venture due to
expenses paid on
              behalf of the joint venture. Please expand your disclosures
pursuant to IFRS 12.23 to
              discuss risks associated with your interests including any
commitments you have in
              place related to the joint venture;
             Please help us understand what led to reversal of provision for
impairment loss on
              interest in joint venture recorded during the period ended March
31, 2021;
             We note your statement on page 74 that you do not have business
operations and
              or offer your services and products in Mainland China. Please
help us understand
              what consideration you gave to this joint venture in making this
statement.
Note 30. Acquisition, page F-48

52.      We note that the intellectual property rights intangible asset
recorded from the Oxsed
         Limited acquisition represent approximately 22% of your total assets
at December 31,
         2020. In this regard, please help us better understand how you
determined the appropriate
         useful life of this intangible asset to be 20 years pursuant to IAS
38.88 through 96.
Exhibits

53.      Please file an opinion as to the material tax consequences of the
domestication and the
         merger. Refer to Item 601(b)(8) of Regulation S-K and Section III.A.2
of Staff Legal
         Bulletin No. 19.
 Danny Yeung
Prenetics Global Limited
October 28, 2021
Page 12

       You may contact Nudrat Salik at 202-551-3692 or Mary Mast at
202-551-3613 if you
have questions regarding comments on the financial statements and related
matters. Please
contact Alan Campbell at 202-551-4224 or Laura Crotty at 202-551-7614 with any
other
questions.



                                                         Sincerely,
FirstName LastNameDanny Yeung
                                                         Division of
Corporation Finance
Comapany NamePrenetics Global Limited
                                                         Office of Life
Sciences
October 28, 2021 Page 12
cc:       Steve Lin
FirstName LastName